Tumor necrosis factor receptor superfamily member 10B

BE0003433ProteinHumansTNFRSF10B

Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). It is acted on by 10 drugs in DrugBank.

Gene name
TNFRSF10B
UniProtKB entry
O14763Swiss-Prot
Cellular location
Membrane
Residues / weight
440 residues · 47,878 Da
Also known as
Death receptor 5 · DR5 · KILLER · TNF-related apoptosis-inducing ligand receptor 2 · TRAIL receptor 2

Resolves to

Protein
UniProtO14763UniProt nameTR10B_HUMAN
Gene
HGNCHGNC:11905NCBI Gene8795GeneCardsTNFRSF10B
Pharmacology
IUPHAR/GtoPdb1880KEGGhsa:8795
Structure
PDB1D0GPDB1D4VPDB1DU3
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
3Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
11GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
40+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Tumor necrosis factor receptor superfamily member 10B, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In