Thrombopoietin receptor

BE0003440ProteinHumansMPL

Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. It is acted on by 10 drugs in DrugBank.

Gene name
MPL
UniProtKB entry
P40238Swiss-Prot
Cellular location
Cell membrane
Residues / weight
635 residues · 71,244 Da
Also known as
Myeloproliferative leukemia protein · Proto-oncogene c-Mpl · TPO-R · TPOR

Resolves to

Protein
UniProtP40238UniProt nameTPOR_HUMAN
Gene
HGNCHGNC:7217NCBI Gene4352GeneCardsMPL
Pharmacology
IUPHAR/GtoPdb1722KEGGhsa:4352
Structure
PDB8G04
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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29Clinical trialsTrials of drugs acting on it, by phase and status
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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35+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Thrombopoietin receptor, how selective are they, and which programs against it are still in active trials?

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