This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Thrombopoietin
DrugBank Accession Number
DB06534
Background

Not Available

Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Other protein based therapies
Protein Chemical Formula
Not Available
Protein Average Weight
Not Available
Sequences
Not Available
Synonyms
Not Available

Pharmacology

Indication

Investigated for use/treatment in thrombocytopenia.

Pharmacology
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Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
UThrombopoietin receptorNot AvailableHumans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
CyclophosphamideThe risk or severity of pulmonary toxicity can be increased when Thrombopoietin is combined with Cyclophosphamide.
VinblastineThe risk or severity of peripheral neuropathy can be increased when Thrombopoietin is combined with Vinblastine.
VincristineThe risk or severity of peripheral neuropathy can be increased when Thrombopoietin is combined with Vincristine.
VindesineThe risk or severity of peripheral neuropathy can be increased when Thrombopoietin is combined with Vindesine.
VinflunineThe risk or severity of peripheral neuropathy can be increased when Thrombopoietin is combined with Vinflunine.
VinorelbineThe risk or severity of peripheral neuropathy can be increased when Thrombopoietin is combined with Vinorelbine.
Interactions
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Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
5651J3R2JF
CAS number
9014-42-0

References

General References
Not Available
Wikipedia
Thrombopoietin

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedTreatmentAplastic Anemia1
3CompletedTreatmentHematologic Diseases / Thrombocytopenia1
2, 3Unknown StatusTreatmentHematological Diseases / Thrombocytopenia1
Not AvailableCompletedTreatmentNeoplasms, Gynecologic1
Not AvailableRecruitingNot AvailableIdiopathic Thrombocytopenic Purpura1
Not AvailableUnknown StatusNot AvailableHemostatic Disorders1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available

Targets

Drugtargets2
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Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Transmembrane signaling receptor activity
Specific Function
Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
Gene Name
MPL
Uniprot ID
P40238
Uniprot Name
Thrombopoietin receptor
Molecular Weight
71244.08 Da

Drug created at March 19, 2008 16:36 / Updated at June 12, 2020 16:52