T-cell surface glycoprotein CD3 gamma chain

BE0003457ProteinHumansCD3G

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. It is acted on by 1 drug in DrugBank.

Gene name
CD3G
UniProtKB entry
P09693Swiss-Prot
Cellular location
Cell membrane
Residues / weight
182 residues · 20,469 Da
Also known as
T-cell receptor T3 gamma chain · T3G

Resolves to

Protein
UniProtP09693UniProt nameCD3G_HUMAN
Gene
HGNCHGNC:1675NCBI Gene917GeneCardsCD3G
Pharmacology
KEGGhsa:917
Structure
PDB1SY6PDB6JXRPDB7FJD
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on T-cell surface glycoprotein CD3 gamma chain, how selective are they, and which programs against it are still in active trials?

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