Interleukin-5 receptor subunit alpha

BE0003471ProteinHumansIL5RA

Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:9378992). It is acted on by 2 drugs in DrugBank.

Gene name
IL5RA
UniProtKB entry
Q01344Swiss-Prot
Cellular location
Membrane
Residues / weight
420 residues · 47,684 Da
Also known as
CDw125 · IL-5 receptor subunit alpha · IL-5R subunit alpha · IL-5R-alpha · IL-5RA

Resolves to

Protein
UniProtQ01344UniProt nameIL5RA_HUMAN
Gene
HGNCHGNC:6017NCBI Gene3568GeneCardsIL5RA
Pharmacology
IUPHAR/GtoPdb1706KEGGhsa:3568
Structure
PDB1OBXPDB1OBZPDB3QT2
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Interleukin-5 receptor subunit alpha, how selective are they, and which programs against it are still in active trials?

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