Activin receptor type-2A

BE0003472ProteinHumansACVR2A

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. It is acted on by 2 drugs in DrugBank.

Gene name
ACVR2A
UniProtKB entry
P27037Swiss-Prot
Cellular location
Cell membrane
Residues / weight
513 residues · 57,847 Da
Also known as
2.7.11.30 · Activin receptor type IIA · ACTR-IIA · ACTRIIA · ACVR2

Resolves to

Protein
UniProtP27037UniProt nameAVR2A_HUMAN
Gene
HGNCHGNC:173NCBI Gene92GeneCardsACVR2A
Pharmacology
IUPHAR/GtoPdb1791KEGGhsa:92
Structure
PDB3Q4TPDB3SOCPDB4ASX
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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16GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Activin receptor type-2A, how selective are they, and which programs against it are still in active trials?

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