This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Sotatercept
DrugBank Accession Number
DB12118
Background

Sotatercept has been used in trials studying the supportive care and treatment of Anemia, Leukemia, Solid Tumors, Bladder Cancer, and multiple myeloma, among others.

Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Fusion proteins
Protein Chemical Formula
Not Available
Protein Average Weight
Not Available
Sequences
Not Available
Synonyms
  • Sotatercept
External IDs
  • ACE-011

Pharmacology

Indication

Not Available

Pharmacology
Reduce drug development failure rates
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Contraindications & Blackbox Warnings
Contraindications
Avoid life-threatening adverse drug events
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Avoid life-threatening adverse drug events & improve clinical decision support.
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Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
UActivin receptor type-2ANot AvailableHumans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbciximabThe risk or severity of adverse effects can be increased when Abciximab is combined with Sotatercept.
AdalimumabThe risk or severity of adverse effects can be increased when Adalimumab is combined with Sotatercept.
AducanumabThe risk or severity of adverse effects can be increased when Sotatercept is combined with Aducanumab.
AlemtuzumabThe risk or severity of adverse effects can be increased when Alemtuzumab is combined with Sotatercept.
AlirocumabThe risk or severity of adverse effects can be increased when Alirocumab is combined with Sotatercept.
AmivantamabThe risk or severity of adverse effects can be increased when Sotatercept is combined with Amivantamab.
AnifrolumabThe risk or severity of adverse effects can be increased when Anifrolumab is combined with Sotatercept.
AnsuvimabThe risk or severity of adverse effects can be increased when Sotatercept is combined with Ansuvimab.
Anthrax immune globulin humanThe risk or severity of adverse effects can be increased when Anthrax immune globulin human is combined with Sotatercept.
Antilymphocyte immunoglobulin (horse)The risk or severity of adverse effects can be increased when Antilymphocyte immunoglobulin (horse) is combined with Sotatercept.
Interactions
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Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
0QI90BTJ37
CAS number
1001080-50-7

References

General References
Not Available
PubChem Substance
347911284

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3Not Yet RecruitingTreatmentPulmonary Arterial Hypertension (PAH)1
3RecruitingTreatmentPAH1
3RecruitingTreatmentPulmonary Arterial Hypertension (PAH)2
2Active Not RecruitingTreatmentBeta Thalassemia Intermedia / Thalassemia Majors (Beta-Thalassemia Major)1
2Active Not RecruitingTreatmentPulmonary Arterial Hypertension (PAH)2
2CompletedTreatmentAnemia1
2CompletedTreatmentAnemia / Chronic Myelomonocytic Leukemia (CMML) / Low to Intermediate-1 MDS / Myelodysplastic Syndromes (MDS)1
2CompletedTreatmentAnemia / Renal Failure, Chronic Renal Failure1
2CompletedTreatmentMultiple Myeloma (MM)1
2Not Yet RecruitingTreatmentCpc-PH Due to HFpEF (Combined Post-capillary and Pre-capillary Pulmonary Hypertension Due to Heart Failure With Preserved Ejection Fraction)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Targets

Drugtargets2
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Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Transmembrane receptor protein serine/threonine kinase activity
Specific Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which auto...
Gene Name
ACVR2A
Uniprot ID
P27037
Uniprot Name
Activin receptor type-2A
Molecular Weight
57847.12 Da

Drug created at October 20, 2016 21:23 / Updated at February 21, 2021 18:53