Leukotriene B4 receptor 1
Details
- Name
- Leukotriene B4 receptor 1
- Kind
- protein
- Synonyms
- BLT
- BLT1
- BLTR
- Chemoattractant receptor-like 1
- CMKRL1
- G-protein coupled receptor 16
- GPR16
- LTB4-R 1
- LTB4-R1
- P2RY7
- P2Y purinoceptor 7
- P2Y7
- Gene Name
- LTB4R
- UniProtKB Entry
- Q15722Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0006762|Leukotriene B4 receptor 1 MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNL ALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVA RPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAF HLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVV NLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGF VAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
- Number of residues
- 352
- Molecular Weight
- 37556.925
- Theoretical pI
- 11.63
- GO Classification
- FunctionsG protein-coupled peptide receptor activityProcessesG protein-coupled receptor signaling pathway / phospholipase C-activating G protein-coupled receptor signaling pathway
- General Function
- Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response
- Specific Function
- G protein-coupled peptide receptor activity
- Pfam Domain Function
- 7tm_1 (PF00001)
- Signal Regions
- Not Available
- Transmembrane Regions
- 20-42 55-75 92-113 139-159 179-199 222-242 269-289
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0012433|Leukotriene B4 receptor 1 (LTB4R) ATGAACACTACATCTTCTGCAGCACCCCCCTCACTAGGTGTAGAGTTCATCTCTCTGCTG GCTATCATCCTGCTGTCAGTGGCGCTGGCTGTGGGGCTTCCCGGCAACAGCTTTGTGGTG TGGAGTATCCTGAAAAGGATGCAGAAGCGCTCTGTCACTGCCCTGATGGTGCTGAACCTG GCCCTGGCCGACCTGGCCGTATTGCTCACTGCTCCCTTTTTCCTTCACTTCCTGGCCCAA GGCACCTGGAGTTTTGGACTGGCTGGTTGCCGCCTGTGTCACTATGTCTGCGGAGTCAGC ATGTACGCCAGCGTCCTGCTTATCACGGCCATGAGTCTAGACCGCTCACTGGCGGTGGCC CGCCCCTTTGTGTCCCAGAAGCTACGCACCAAGGCGATGGCCCGGCGGGTGCTGGCAGGC ATCTGGGTGTTGTCCTTTCTGCTGGCCACACCCGTCCTCGCGTACCGCACAGTAGTGCCC TGGAAAACGAACATGAGCCTGTGCTTCCCGCGGTACCCCAGCGAAGGGCACCGGGCCTTC CATCTAATCTTCGAGGCTGTCACGGGCTTCCTGCTGCCCTTCCTGGCTGTGGTGGCCAGC TACTCGGACATAGGGCGTCGGCTACAGGCCCGGCGCTTCCGCCGCAGCCGCCGCACCGGC CGCCTGGTGGTGCTCATCATCCTGACCTTCGCCGCCTTCTGGCTGCCCTACCACGTGGTG AACCTGGCTGAGGCGGGCCGCGCGCTGGCCGGCCAGGCCGCCGGGTTAGGGCTCGTGGGG AAGCGGCTGAGCCTGGCCCGCAACGTGCTCATCGCACTCGCCTTCCTGAGCAGCAGCGTG AACCCCGTGCTGTACGCGTGCGCCGGCGGCGGCCTGCTGCGCTCGGCGGGCGTGGGCTTC GTCGCCAAGCTGCTGGAGGGCACGGGCTCCGAGGCGTCCAGCACGCGCCGCGGGGGCAGC CTGGGCCAGACCGCTAGGAGCGGCCCCGCCGCTCTGGAGCCCGGCCCTTCCGAGAGCCTC ACTGCCTCCAGCCCTCTCAAGTTAAACGAACTGAACTAG
- Chromosome Location
- 14
- Locus
- 14q12
- External Identifiers
Resource Link UniProtKB ID Q15722 UniProtKB Entry Name LT4R1_HUMAN GenBank Gene ID BC004545 GeneCard ID LTB4R GenAtlas ID LTB4R HGNC ID HGNC:6713 PDB ID(s) 7K15, 7VKT KEGG ID hsa:1241 IUPHAR/Guide To Pharmacology ID 267 NCBI Gene ID 1241 - General References
- Akbar GK, Dasari VR, Webb TE, Ayyanathan K, Pillarisetti K, Sandhu AK, Athwal RS, Daniel JL, Ashby B, Barnard EA, Kunapuli SP: Molecular cloning of a novel P2 purinoceptor from human erythroleukemia cells. J Biol Chem. 1996 Aug 2;271(31):18363-7. [Article]
- Raport CJ, Schweickart VL, Chantry D, Eddy RL Jr, Shows TB, Godiska R, Gray PW: New members of the chemokine receptor gene family. J Leukoc Biol. 1996 Jan;59(1):18-23. [Article]
- Yokomizo T, Izumi T, Chang K, Takuwa Y, Shimizu T: A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature. 1997 Jun 5;387(6633):620-4. [Article]
- Owman C, Nilsson C, Lolait SJ: Cloning of cDNA encoding a putative chemoattractant receptor. Genomics. 1996 Oct 15;37(2):187-94. [Article]
- Kato K, Yokomizo T, Izumi T, Shimizu T: Cell-specific transcriptional regulation of human leukotriene B(4) receptor gene. J Exp Med. 2000 Aug 7;192(3):413-20. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Gaudreau R, Le Gouill C, Venne MH, Stankova J, Rola-Pleszczynski M: Threonine 308 within a putative casein kinase 2 site of the cytoplasmic tail of leukotriene B(4) receptor (BLT1) is crucial for ligand-induced, G-protein-coupled receptor-specific kinase 6-mediated desensitization. J Biol Chem. 2002 Aug 30;277(35):31567-76. Epub 2002 Jun 20. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Amelubant investigational yes target antagonist Details Leukotriene B4 investigational yes target agonist Details Morniflumate experimental unknown target antagonist Details CP-195543 investigational yes target antagonist Details Etalocib investigational yes target antagonist Details SC 41930 investigational yes target binder Details