Parathyroid hormone/parathyroid hormone-related peptide receptor

BE0003508ProteinHumansPTH1R

G protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH) (PubMed:10913300, PubMed:11773434, PubMed:18375760, PubMed:19674967, PubMed:27160269, PubMed:30975883, PubMed:35932760, PubMed:8397094). It is acted on by 8 drugs in DrugBank.

Gene name
PTH1R
UniProtKB entry
Q03431Swiss-Prot
Cellular location
Cell membrane
Residues / weight
593 residues · 66,360 Da
Also known as
Parathyroid hormone 1 receptor · PTH/PTHr receptor · PTH/PTHrP type I receptor · PTH1 receptor · PTHR

Resolves to

Protein
UniProtQ03431UniProt namePTH1R_HUMAN
Gene
HGNCHGNC:9608NCBI Gene5745GeneCardsPTH1R
Pharmacology
IUPHAR/GtoPdb331KEGGhsa:5745
Structure
PDB1BL1PDB3C4MPDB3H3G
Drugs

What you can answer from here — as of September 07, 2019

8DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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43+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Parathyroid hormone/parathyroid hormone-related peptide receptor, how selective are they, and which programs against it are still in active trials?

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