Parathyroid hormone is an analog of human parathyroid hormone (PTH) used to treat hypocalcemia caused by hypoparathyroidism. Parathyroid hormone (PTH) is a single-chain polypeptide composed of 84 amino acids.
- Mechanism
- Curator reviewed
The biological actions of rhPTH are mediated through binding to at least two distinct high- affinity cell-surface receptors specific for the N-terminal and C-terminal regions of the molecule, both of which are required for normal bone metabolism. The N-terminal portion of the molecule is primarily responsible for the bone building effects of parathyroid hormone. The C-terminal portion of the molecule has antiresorptive activity and is necessary for normal regulation of N-terminal fragment activity.
- Primary indication
- For use/treatment in osteoporosis.Curator reviewed · 2 structured indications
- Formula / weight
- C408H674N126O126S2 · 9420.0 Da
- First approval
- United States, 2015
- Also known as
- Parathormone · Parathormone (human recombinant) · Parathyrin · PTH
- Code names
- ALX-1-11 · NPSP-558
- Brand names
Resolves to
What you can answer from here — as of June 15, 2026
Which drugs share a target with Parathyroid hormone, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account