Toll-like receptor 8

BE0003518ProteinHumansTLR8

Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876, PubMed:32433612). It is acted on by 10 drugs in DrugBank.

Gene name
TLR8
UniProtKB entry
Q9NR97Swiss-Prot
Cellular location
Endosome membrane
Residues / weight
1,041 residues · 119,827 Da

Resolves to

Protein
UniProtQ9NR97UniProt nameTLR8_HUMAN
Gene
HGNCHGNC:15632NCBI Gene51311GeneCardsTLR8
Pharmacology
IUPHAR/GtoPdb1758KEGGhsa:51311
Structure
PDB3W3GPDB3W3JPDB3W3K
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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9Clinical trialsTrials of drugs acting on it, by phase and status
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16GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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41+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Toll-like receptor 8, how selective are they, and which programs against it are still in active trials?

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