Thiamine transporter 1

BE0003530ProteinHumansSLC19A2

High-affinity transporter for the intake of thiamine (PubMed:10391222, PubMed:10542220, PubMed:21836059, PubMed:33008889, PubMed:35512554, PubMed:35724964). It is acted on by 2 drugs in DrugBank.

Gene name
SLC19A2
UniProtKB entry
O60779Swiss-Prot
Cellular location
Cell membrane
Residues / weight
497 residues · 55,399 Da
Also known as
Solute carrier family 19 member 2 · TC1 · Thiamine carrier 1 · THT1 · ThTr-1

Resolves to

Protein
UniProtO60779UniProt nameS19A2_HUMAN
Gene
HGNCHGNC:10938NCBI Gene10560GenBank6524689GeneCardsSLC19A2
Pharmacology
KEGGhsa:10560
Structure
PDB8Z7ZPDB8Z80
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Thiamine transporter 1, how selective are they, and which programs against it are still in active trials?

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