Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A

BE0003565ProteinHumansPDE1A

Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. It is acted on by 5 drugs in DrugBank.

Gene name
PDE1A
UniProtKB entry
P54750Swiss-Prot
Residues / weight
535 residues · 61,251 Da
Also known as
3.1.4.17 · 61 kDa Cam-PDE · Cam-PDE 1A · hCam-1

Resolves to

Protein
UniProtP54750UniProt namePDE1A_HUMAN
Gene
HGNCHGNC:8774NCBI Gene5136GenBank1151109GeneCardsPDE1A
Pharmacology
IUPHAR/GtoPdb1294KEGGhsa:5136
Drugs

What you can answer from here — as of September 03, 2024

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, how selective are they, and which programs against it are still in active trials?

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