V-type proton ATPase catalytic subunit A

BE0003569ProteinHumansATP6V1A

Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:8463241, PubMed:22053050). It is acted on by 4 drugs in DrugBank.

Gene name
ATP6V1A
UniProtKB entry
P38606Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
617 residues · 68,304 Da
Also known as
7.1.2.2 · ATP6A1 · ATP6V1A1 · V-ATPase 69 kDa subunit · V-ATPase subunit A

Resolves to

Protein
UniProtP38606UniProt nameVATA_HUMAN
Gene
HGNCHGNC:851NCBI Gene523GenBank291868GeneCardsATP6V1A
Pharmacology
KEGGhsa:523
Structure
PDB6WLZPDB6WM2PDB6WM3
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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26GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on V-type proton ATPase catalytic subunit A, how selective are they, and which programs against it are still in active trials?

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