Bafilomycin A1

DB06733ExperimentalSmall molecule

The bafilomycins refer to a category of toxic macrolide antibiotics that are derivatives of Streptomyces griseus. These compounds all appear in the same fermentation and have similar biological activity. Bafilomycins... Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase.

Mechanism: The bafilomycins are a family of toxic macrolide antibiotic derived from Streptomyces griseus. These compounds all appear in the same fermentation and have quite similar biological activity. Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase. (V-ATPase).
Curator reviewed
Formula / weight: C₃₅H₅₈O₉ · 622.84 g/mol (avg)

Resolves to

Compound

CAS88899-55-2ChEMBLCHEMBL290814ChEBI22689PubChem6436223

Structure

InChIKeyXDHNQDDQEHDUTM-JQWOJBOSSA-NSMILES

CO[C@H]1\C=C\C=C(C)\C[C@H](C)[C@H](O)[C@H](C)\C=C(/C)\C=C(OC)\C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](O)[C@H](C)[C@H](O1)C(C)C

Targets

P38606ATP6V1A

What you can answer from here — as of April 02, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

14Drug interactionsStructured to mechanism, not free text

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with Bafilomycin A1, and which of those have an active Phase 3 trial?

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