Geranylgeranyl pyrophosphate synthase

BE0003570ProteinHumansGGPS1

Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. It is acted on by 15 drugs in DrugBank.

Gene name
GGPS1
UniProtKB entry
O95749Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
300 residues · 34,871 Da
Also known as
(2E,6E)-farnesyl diphosphate synthase · 2.5.1.- · Dimethylallyltranstransferase · Farnesyl diphosphate synthase · Farnesyltranstransferase

Resolves to

Protein
UniProtO95749UniProt nameGGPPS_HUMAN
Gene
HGNCHGNC:4249NCBI Gene9453GenBank4520350GeneCardsGGPS1
Pharmacology
IUPHAR/GtoPdb643KEGGhsa:9453
Structure
PDB2Q80PDB6C56PDB6C57
Drugs

What you can answer from here — as of September 07, 2019

15DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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43+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Geranylgeranyl pyrophosphate synthase, how selective are they, and which programs against it are still in active trials?

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