Major histocompatibility complex class I-related protein 1

BE0003573ProteinHumansMR1

Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells (PubMed:19416870, PubMed:23457030, PubMed:22692454, PubMed:23051753, PubMed:24101382, PubMed:23846752, PubMed:26795251). It is acted on by 3 drugs in DrugBank.

Gene name
MR1
UniProtKB entry
Q95460Swiss-Prot
Cellular location
Cell membrane
Residues / weight
341 residues · 39,366 Da
Also known as
Class I histocompatibility antigen-like protein · MHC class I-related protein 1

Resolves to

Protein
UniProtQ95460UniProt nameHMR1_HUMAN
Gene
HGNCHGNC:4975NCBI Gene3140GenBank940354GeneCardsMR1
Pharmacology
KEGGhsa:3140
Structure
PDB4GUPPDB4L4TPDB4L4V
Drugs

What you can answer from here — as of June 26, 2025

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Major histocompatibility complex class I-related protein 1, how selective are they, and which programs against it are still in active trials?

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