Neuronal acetylcholine receptor subunit alpha-5

BE0003586ProteinHumansCHRNA5

Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate... It is acted on by 2 drugs in DrugBank.

Gene name
CHRNA5
UniProtKB entry
P30532Swiss-Prot
Cellular location
Synaptic cell membrane
Residues / weight
468 residues · 53,054 Da
Also known as
NACHRA5

Resolves to

Protein
UniProtP30532UniProt nameACHA5_HUMAN
Gene
HGNCHGNC:1959NCBI Gene1138GenBank177926GeneCardsCHRNA5
Pharmacology
KEGGhsa:1138
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Neuronal acetylcholine receptor subunit alpha-5, how selective are they, and which programs against it are still in active trials?

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