Neuronal acetylcholine receptor subunit beta-3

BE0003588ProteinHumansCHRNB3

Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate... It is acted on by 2 drugs in DrugBank.

Gene name
CHRNB3
UniProtKB entry
Q05901Swiss-Prot
Cellular location
Synaptic cell membrane
Residues / weight
458 residues · 52,728 Da

Resolves to

Protein
UniProtQ05901UniProt nameACHB3_HUMAN
Gene
HGNCHGNC:1963NCBI Gene1142GenBank1458124GeneCardsCHRNB3
Pharmacology
KEGGhsa:1142
Structure
PDB8A5U
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Neuronal acetylcholine receptor subunit beta-3, how selective are they, and which programs against it are still in active trials?

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