Gamma-aminobutyric acid receptor subunit gamma-1

BE0003593ProteinHumansGABRG1

Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790). It is acted on by 3 drugs in DrugBank.

Gene name
GABRG1
UniProtKB entry
Q8N1C3Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
465 residues · 53,594 Da
Also known as
GABA(A) receptor subunit gamma-1 · GABAAR subunit gamma-1

Resolves to

Protein
UniProtQ8N1C3UniProt nameGBRG1_HUMAN
Gene
HGNCHGNC:4086NCBI Gene2565GenBank193783776GeneCardsGABRG1
Pharmacology
KEGGhsa:2565
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gamma-aminobutyric acid receptor subunit gamma-1, how selective are they, and which programs against it are still in active trials?

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