Gamma-aminobutyric acid receptor subunit epsilon

BE0003595ProteinHumansGABRE

Epsilon subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:16412217, PubMed:9882711). It is acted on by 2 drugs in DrugBank.

Gene name
GABRE
UniProtKB entry
P78334Swiss-Prot
Cellular location
Cell membrane
Residues / weight
506 residues · 57,971 Da
Also known as
GABA(A) receptor subunit epsilon · GABAAR subunit epsilon

Resolves to

Protein
UniProtP78334UniProt nameGBRE_HUMAN
Gene
HGNCHGNC:4085NCBI Gene2564GenBank1857126GeneCardsGABRE
Pharmacology
KEGGhsa:2564
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gamma-aminobutyric acid receptor subunit epsilon, how selective are they, and which programs against it are still in active trials?

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