Gamma-aminobutyric acid receptor subunit pi

BE0003596ProteinHumansGABRP

Pi subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA) (PubMed:10462548). It is acted on by 2 drugs in DrugBank.

Gene name
GABRP
UniProtKB entry
O00591Swiss-Prot
Cellular location
Cell membrane
Residues / weight
440 residues · 50,640 Da
Also known as
GABA(A) receptor subunit pi · GABAAR subunit pi

Resolves to

Protein
UniProtO00591UniProt nameGBRP_HUMAN
Gene
HGNCHGNC:4089NCBI Gene2568GenBank2197001GeneCardsGABRP
Pharmacology
KEGGhsa:2568
Structure
PDB8VSZPDB8VV0
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gamma-aminobutyric acid receptor subunit pi, how selective are they, and which programs against it are still in active trials?

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