Gamma-aminobutyric acid receptor subunit theta

BE0003597ProteinHumansGABRQ

Theta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790, PubMed:16412217). It is acted on by 1 drug in DrugBank.

Gene name
GABRQ
UniProtKB entry
Q9UN88Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
632 residues · 71,987 Da
Also known as
GABA(A) receptor subunit theta · GABAAR subunit theta

Resolves to

Protein
UniProtQ9UN88UniProt nameGBRT_HUMAN
Gene
HGNCHGNC:14454NCBI Gene55879GenBank7861736GeneCardsGABRQ
Pharmacology
KEGGhsa:55879
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gamma-aminobutyric acid receptor subunit theta, how selective are they, and which programs against it are still in active trials?

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