Aldo-keto reductase family 1 member D1

BE0003610ProteinHumansAKR1D1

Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. It is acted on by 7 drugs in DrugBank.

Gene name
AKR1D1
UniProtKB entry
P51857Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
326 residues · 37,377 Da
Also known as
1.3.1.3 · 3-oxo-5-beta-steroid 4-dehydrogenase · Delta(4)-3-ketosteroid 5-beta-reductase · Delta(4)-3-oxosteroid 5-beta-reductase · SRD5B1

Resolves to

Protein
UniProtP51857UniProt nameAK1D1_HUMAN
Gene
HGNCHGNC:388NCBI Gene6718GenBank431857GeneCardsAKR1D1
Pharmacology
KEGGhsa:6718
Structure
PDB3BURPDB3BUVPDB3BV7
Drugs

What you can answer from here — as of September 03, 2024

7DrugsApproved to experimental, with action, bond type and pharmacological action
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aldo-keto reductase family 1 member D1, how selective are they, and which programs against it are still in active trials?

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