DNA polymerase epsilon catalytic subunit A

BE0003614ProteinHumansPOLE

Catalytic component of the DNA polymerase epsilon complex (PubMed:10801849). It is acted on by 1 drug in DrugBank.

Gene name
POLE
UniProtKB entry
Q07864Swiss-Prot
Cellular location
Nucleus
Residues / weight
2,286 residues · 261,516 Da
Also known as
2.7.7.7 · 3'-5' exodeoxyribonuclease · DNA polymerase II subunit A · POLE1

Resolves to

Protein
UniProtQ07864UniProt nameDPOE1_HUMAN
Gene
HGNCHGNC:9177NCBI Gene5426GenBank3192938GeneCardsPOLE
Pharmacology
KEGGhsa:5426
Structure
PDB5VBNPDB7PFOPDB7PLO
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA polymerase epsilon catalytic subunit A, how selective are they, and which programs against it are still in active trials?

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