DNA polymerase epsilon subunit 2

BE0003615ProteinHumansPOLE2

Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). It is acted on by 2 drugs in DrugBank.

Gene name
POLE2
UniProtKB entry
P56282Swiss-Prot
Cellular location
Nucleus
Residues / weight
527 residues · 59,537 Da
Also known as
DNA polymerase epsilon subunit B · DNA polymerase II subunit 2 · DPE2

Resolves to

Protein
UniProtP56282UniProt nameDPOE2_HUMAN
Gene
HGNCHGNC:9178NCBI Gene5427GenBank2697123GeneCardsPOLE2
Pharmacology
KEGGhsa:5427
Structure
PDB2V6ZPDB5VBNPDB7PFO
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA polymerase epsilon subunit 2, how selective are they, and which programs against it are still in active trials?

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