Gamma-aminobutyric acid receptor subunit rho-3

BE0003619ProteinHumansGABRR3

Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (By similarity). It is acted on by 2 drugs in DrugBank.

Gene name
GABRR3
UniProtKB entry
A8MPY1Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
467 residues · 54,271 Da
Also known as
GABA(A) receptor subunit rho-3 · GABA(C) receptor · GABAAR subunit rho-3

Resolves to

Protein
UniProtA8MPY1UniProt nameGBRR3_HUMAN
Gene
HGNCHGNC:17969NCBI Gene200959GeneCardsGABRR3
Pharmacology
KEGGhsa:200959
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Gamma-aminobutyric acid receptor subunit rho-3, and which indications are they being tested in?

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