Cation-independent mannose-6-phosphate receptor

BE0003623ProteinHumansIGF2R

Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:18817523, PubMed:2963003). It is acted on by 11 drugs in DrugBank.

Gene name
IGF2R
UniProtKB entry
P11717Swiss-Prot
Cellular location
Golgi apparatus membrane
Residues / weight
2,491 residues · 274,372 Da
Also known as
300 kDa mannose 6-phosphate receptor · CI Man-6-P receptor · CI-MPR · IGF-II receptor · Insulin-like growth factor 2 receptor

Resolves to

Protein
UniProtP11717UniProt nameMPRI_HUMAN
Gene
HGNCHGNC:5467NCBI Gene3482GenBank33055GeneCardsIGF2R
Pharmacology
KEGGhsa:3482
Structure
PDB1E6FPDB1GP0PDB1GP3
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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14GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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45+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cation-independent mannose-6-phosphate receptor, how selective are they, and which programs against it are still in active trials?

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