NAV

Mannose 6-phosphate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Mannose 6-phosphate
DrugBank Accession Number
DB11848
Background

Mannose 6-phosphate has been used in trials studying the treatment of Wound, Cicatrix, Wound-healing, and Re-epithelialisation.

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 260.1358
Monoisotopic: 260.029718526
Chemical Formula
C6H13O9P
Synonyms
  • Juvidex
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Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as monosaccharide phosphates. These are monosaccharides comprising a phosphated group linked to the carbohydrate unit.
Kingdom
Organic compounds
Super Class
Organic oxygen compounds
Class
Organooxygen compounds
Sub Class
Carbohydrates and carbohydrate conjugates
Direct Parent
Monosaccharide phosphates
Alternative Parents
Monoalkyl phosphates / Beta-hydroxy aldehydes / Alpha-hydroxyaldehydes / Secondary alcohols / Polyols / Organic oxides / Hydrocarbon derivatives
Substituents
Alcohol / Aldehyde / Aliphatic acyclic compound / Alkyl phosphate / Alpha-hydroxyaldehyde / Beta-hydroxy aldehyde / Carbonyl group / Hydrocarbon derivative / Monoalkyl phosphate / Monosaccharide phosphate
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
D-mannose 6-phosphate (CHEBI:48042)
Affected organisms
Not Available

Chemical Identifiers

UNII
U2S53JF879
CAS number
3672-15-9
InChI Key
VFRROHXSMXFLSN-KVTDHHQDSA-N
InChI
InChI=1S/C6H13O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h1,3-6,8-11H,2H2,(H2,12,13,14)/t3-,4-,5-,6-/m1/s1
IUPAC Name
{[(2R,3R,4S,5S)-2,3,4,5-tetrahydroxy-6-oxohexyl]oxy}phosphonic acid
SMILES
[H][C@@](O)(COP(O)(O)=O)[C@@]([H])(O)[C@]([H])(O)[C@]([H])(O)C=O

References

General References
Not Available
PubChem Compound
6101690
PubChem Substance
347828192
ChemSpider
4809693
ChEBI
48042
ZINC
ZINC000002508229
Wikipedia
Mannose_6-phosphate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2CompletedTreatmentCicatrix / Promotion of wound healing1
1CompletedTreatmentCicatrix / Re-epithelialisation1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility21.7 mg/mLALOGPS
logP-1.8ALOGPS
logP-3.7Chemaxon
logS-1.1ALOGPS
pKa (Strongest Acidic)1.49Chemaxon
pKa (Strongest Basic)-3.5Chemaxon
Physiological Charge-2Chemaxon
Hydrogen Acceptor Count8Chemaxon
Hydrogen Donor Count6Chemaxon
Polar Surface Area164.75 Å2Chemaxon
Rotatable Bond Count7Chemaxon
Refractivity48.22 m3·mol-1Chemaxon
Polarizability20.91 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
GC-MS Spectrum - GC-MS (1 MEOX; 6 TMS)GC-MSsplash10-00ks-1956000000-05fcbd5dbfce446947f1
GC-MS Spectrum - GC-MS (1 MEOX; 6 TMS)GC-MSsplash10-000i-1957000000-d4b27ee269941af3a813
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSsplash10-0007-9640000000-89efc5d69e8c7bfb4553
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-01ow-5390000000-088e9052b81b40906b96
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0002-9300000000-59f9c073bf1e2f1ecf5d
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-002b-9000000000-7ca1a8bd16bbff856404
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0002-9200000000-de4c2a0a1164198476e3
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-9000000000-cfd7a3db44e1d0911443
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0002-9000000000-b1d8c748ab2de700fb59
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-149.36554
predicted
DeepCCS 1.0 (2019)
[M+H]+151.66466
predicted
DeepCCS 1.0 (2019)
[M+Na]+158.07732
predicted
DeepCCS 1.0 (2019)

Drug created at October 20, 2016 20:53 / Updated at June 12, 2020 16:53