Carbonic anhydrase 5A, mitochondrial

BE0003626ProteinHumansCA5A

Mitochondrial carbonic anhydrase that catalyzes the reversible conversion of carbon dioxide to bicarbonate/HCO3 (PubMed:24530203, PubMed:8356065, PubMed:16807956, PubMed:16686544, PubMed:17127057, PubMed:17314045, PubMed:19186056, PubMed:19206230). It is acted on by 5 drugs in DrugBank.

Gene name
CA5A
UniProtKB entry
P35218Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
305 residues · 34,750 Da
Also known as
4.2.1.1 · CA-VA · CA5 · Carbonate dehydratase VA · Carbonic anhydrase VA

Resolves to

Protein
UniProtP35218UniProt nameCAH5A_HUMAN
Gene
HGNCHGNC:1377NCBI Gene763GenBank306483GeneCardsCA5A
Pharmacology
KEGGhsa:763
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Carbonic anhydrase 5A, mitochondrial, how selective are they, and which programs against it are still in active trials?

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