Sodium channel regulatory subunit beta-1

BE0003635ProteinHumansSCN1B

Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes (PubMed:40768348). It is acted on by 2 drugs in DrugBank.

Gene name
SCN1B
UniProtKB entry
Q07699Swiss-Prot
Cellular location
Cell membrane
Residues / weight
218 residues · 24,707 Da

Resolves to

Protein
UniProtQ07699UniProt nameSCN1B_HUMAN
Gene
HGNCHGNC:10586NCBI Gene6324GenBank307415GeneCardsSCN1B
Pharmacology
KEGGhsa:6324
Structure
PDB21TPPDB21TQPDB6AGF
Drugs

What you can answer from here — as of October 08, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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23GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium channel regulatory subunit beta-1, how selective are they, and which programs against it are still in active trials?

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