Sodium channel regulatory subunit beta-2

BE0003636ProteinHumansSCN2B

Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes (PubMed:19808477, PubMed:23559163, PubMed:26894959, PubMed:30765605, PubMed:30765606, PubMed:35277491, PubMed:36823201). It is acted on by 1 drug in DrugBank.

Gene name
SCN2B
UniProtKB entry
O60939Swiss-Prot
Cellular location
Cell membrane
Residues / weight
215 residues · 24,326 Da

Resolves to

Protein
UniProtO60939UniProt nameSCN2B_HUMAN
Gene
HGNCHGNC:10589NCBI Gene6327GenBank3309111GeneCardsSCN2B
Pharmacology
KEGGhsa:6327
Structure
PDB21TPPDB21TQPDB5FDY
Drugs

What you can answer from here — as of October 08, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium channel regulatory subunit beta-2, how selective are they, and which programs against it are still in active trials?

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