Sodium channel regulatory subunit beta-4

BE0003638ProteinHumansSCN4B

Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. It is acted on by 1 drug in DrugBank.

Gene name
SCN4B
UniProtKB entry
Q8IWT1Swiss-Prot
Cellular location
Cell membrane
Residues / weight
228 residues · 24,969 Da

Resolves to

Protein
UniProtQ8IWT1UniProt nameSCN4B_HUMAN
Gene
HGNCHGNC:10592NCBI Gene6330GenBank27465047GeneCardsSCN4B
Pharmacology
KEGGhsa:6330
Structure
PDB4MZ2PDB4MZ3PDB5XAW
Drugs

What you can answer from here — as of December 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium channel regulatory subunit beta-4, how selective are they, and which programs against it are still in active trials?

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