Copper-transporting ATPase 1

BE0003666ProteinHumansATP7A

ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). It is acted on by 5 drugs in DrugBank.

Gene name
ATP7A
UniProtKB entry
Q04656Swiss-Prot
Cellular location
Golgi apparatus, trans-Golgi network membrane
Residues / weight
1,500 residues · 163,371 Da
Also known as
7.2.2.8 · Copper pump 1 · MC1 · Menkes disease-associated protein · MNK

Resolves to

Protein
UniProtQ04656UniProt nameATP7A_HUMAN
Gene
HGNCHGNC:869NCBI Gene538GenBank179253GeneCardsATP7A
Pharmacology
KEGGhsa:538
Structure
PDB1AW0PDB1KVIPDB1KVJ
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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47GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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39+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Copper-transporting ATPase 1, how selective are they, and which programs against it are still in active trials?

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