Organic solute transporter subunit alpha

BE0003667ProteinHumansSLC51A

Essential component of the OST-alpha/OST-beta complex, a heterotetramer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed:16317684, PubMed:41606314, PubMed:41606328). It is acted on by 4 drugs in DrugBank.

Gene name
SLC51A
UniProtKB entry
Q86UW1Swiss-Prot
Cellular location
Basolateral cell membrane
Residues / weight
340 residues · 37,735 Da
Also known as
OST-alpha · OSTA · Solute carrier family 51 subunit alpha

Resolves to

Protein
UniProtQ86UW1UniProt nameOSTA_HUMAN
Gene
HGNCHGNC:29955NCBI Gene200931GenBank30348899GeneCardsSLC51A
Pharmacology
KEGGhsa:200931
Structure
PDB9LJGPDB9LJHPDB9UNV
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Organic solute transporter subunit alpha, how selective are they, and which programs against it are still in active trials?

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