Conjugated estrogens is a mixture of estrogens used in estrogen replacement therapy for menopause and hypoestrogenism, used in the treatment of various malignancies, and used in the treatment of postmenopausal osteoporosis. The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material.
- Mechanism
- Curator reviewed · 3 references
The conjugated estrogens, equally to the normal physiological estrogen, work by agonistically binding to the estrogen receptors alpha and beta. The estrogen receptors vary in quantity and proportion according to the tissues and hence, the activity of this conjugated estrogens is very variable.
The activity made by the conjugated estrogens is driven by the increase in the synthesis of DNA, RNA and various proteins in responsive tissues which in order will reduce the release of gonadotropin-releasing hormone, follicle-stimulating hormone and leuteinizing hormone.
The specific mechanism of action cannot be described only in terms of total estrogenic action as the pharmacokinetic profile, the tissue specificity and the tissue metabolism is different for each component of the product.
- Primary indication
- The conjugated estrogens are indicated for several different conditions including: Treatment of moderate to severe vasomotor symptoms due to menopause.Curator reviewed · 24 structured indications
- First approval
- Canada, 1999 · United States, 1956 · European Union, 2016
- Also known as
- Conjugated equine estrogens · Estrogens, Conjugated · Estrogens,conjugated
- Brand names
Resolves to
What you can answer from here — as of July 17, 2026
Which drugs share a target with Conjugated estrogens, and which of those have an active Phase 3 trial?
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