Phospholipid-transporting ATPase ABCA3

BE0003671ProteinHumansABCA3

Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant (PubMed:16959783,... It is acted on by 1 drug in DrugBank.

Gene name
ABCA3
UniProtKB entry
Q99758Swiss-Prot
Cellular location
Endosome, multivesicular body membrane
Residues / weight
1,704 residues · 191,360 Da
Also known as
7.6.2.1 · ABC-C transporter · ABC3 · ATP-binding cassette 3 · ATP-binding cassette sub-family A member 3

Resolves to

Protein
UniProtQ99758UniProt nameABCA3_HUMAN
Gene
HGNCHGNC:33NCBI Gene21GenBank1699038GeneCardsABCA3
Pharmacology
KEGGhsa:21
Structure
PDB7W01PDB7W02
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phospholipid-transporting ATPase ABCA3, how selective are they, and which programs against it are still in active trials?

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