Mitochondrial potassium channel ATP-binding subunit

BE0003673ProteinHumansABCB8

ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)) (PubMed:31435016). It is acted on by 1 drug in DrugBank.

Gene name
ABCB8
UniProtKB entry
Q9NUT2Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
735 residues · 79,988 Da
Also known as
ABCB8 · ATP-binding cassette sub-family B member 8, mitochondrial · M-ABC1 · MABC1 · Mitochondrial ATP-binding cassette 1

Resolves to

Protein
UniProtQ9NUT2UniProt nameMITOS_HUMAN
Gene
HGNCHGNC:49NCBI Gene11194GenBank4321407GeneCardsABCB8
Pharmacology
KEGGhsa:11194
Structure
PDB5OCHPDB7EHL
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitochondrial potassium channel ATP-binding subunit, how selective are they, and which programs against it are still in active trials?

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