Small ribosomal subunit protein uS19

BE0003710ProteinEscherichia coli (strain K12)rpsS

In the E.coli 70S ribosome in the initiation state (PubMed:12809609) it has been modeled to contact the 23S rRNA of the 50S subunit forming part of bridge B1a; this bridge is broken in the model... It is acted on by 4 drugs in DrugBank.

Gene name
rpsS
UniProtKB entry
P0A7U3Swiss-Prot
Residues / weight
92 residues · 10,430 Da
Also known as
30S ribosomal protein S19

Resolves to

Protein
UniProtP0A7U3UniProt nameRS19_ECOLI
Gene
NCBI Gene947811GenBank42826
Pharmacology
KEGGecj:JW3278
Structure
PDB1M5GPDB2YKRPDB3J9Y
Drugs

What you can answer from here — as of May 03, 2025

4DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Small ribosomal subunit protein uS19, how selective are they, and which programs against it are still in active trials?

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