Omadacycline

DB12455ApprovedInvestigationalSmall moleculeTetracyclines

Omadacycline is a tetracycline antibiotic used to treat community acquired bacterial pneumonia. Omadacycline has been used in trials studying the treatment of Bacterial Pneumonia, Bacterial Infections, Community-Acquired Infections, and Skin Structures and Soft Tissue Infections.

Mechanism: Omadacycline binds to the primary tetracycline binding site on the bacterial 30s ribosomal subunit with high specificity. There it acts to block protein synthesis, disrupting many facets of cellular function and resulting in either cell death or stasis.
Curator reviewed · 4 references
Primary indication: Omadacycline is indicated for the treatment of community acquired bacterial pneumonia and acute bacterial skin and skin structure infections caused by omadacycline-susceptible organisms in adults.Curator reviewed · 6 structured indications
Formula / weight: C₂₉H₄₀N₄O₇ · 556.66 g/mol (avg)
First approval: United States, 2019
Also known as: Amadacycline
Code names: BAY 73-6944
Brand names: Nuzyra

Resolves to

Compound

UNII090IP5RV8FCAS389139-89-3ChEMBLCHEMBL1689772PubChem54697325

Clinical / RWD

RxNorm2059269ATCJ01AA15ATCJ01AA20

Structure

InChIKeyJEECQCWWSTZDCK-IQZGDKDPSA-NSMILES[H][C@@]12CC3=C(C=C(CNCC(C)(C)C)C(O)=C3C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2)N(C)C

Targets

P0A7V3rpsCP02359rpsGP0A7W7rpsHP0A7U3rpsSP0AG59rpsN

Transporters

P08183ABCB1

What you can answer from here — as of September 11, 2026

6Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1TransporterSubstrate / inhibitor direction, not just membership

Listed above

518Drug interactionsStructured to mechanism, not free text

21Clinical trialsPhase, status and sponsor resolved per trial

6Structured indicationsCondition, population, route and combination as fields, not prose