DNA gyrase subunit A

BE0003724ProteinStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)gyrA

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. It is acted on by 2 drugs in DrugBank.

Gene name
gyrA
UniProtKB entry
P72524Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
822 residues · 92,053 Da
Also known as
5.6.2.2 · 5.99.1.3

Resolves to

Protein
UniProtP72524UniProt nameGYRA_STRPN
Gene
GenBank14971465
Pharmacology
KEGGspn:SP_1219
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA gyrase subunit A, how selective are they, and which programs against it are still in active trials?

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