Gatifloxacin

DB01044ApprovedInvestigationalWithdrawnSmall moleculeAnti-Bacterial Agents Quinolone Antimicrobial Quinolones

Gatifloxacin is a fourth generation fluoroquinolone used to treat a wide variety of infections in the body. Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family.

Mechanism: The bactericidal action of Gatifloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination.
Curator reviewed
Primary indication: For the treatment of bronchitis, sinusitis, community-acquired pneumonia, and skin infections (abscesses, wounds) caused by S. pneumoniae, H. influenzae, S. aureus, M. pneumoniae, C. pneumoniae, L. pneumophila, S. pyogenesCurator reviewed · 3 structured indications
Formula / weight: C₁₉H₂₂FN₃O₄ · 375.3941 g/mol (avg)
First approval: Canada, 2001 · United States, 2010
Brand names: Zymar
Zymaxid

Resolves to

Compound

UNII81485Y3A9ACAS112811-59-3ChEMBLCHEMBL31ChEBI5280PubChem5379KEGGD08011

Clinical / RWD

RxNorm1546025ATCJ01MA16ATCS01AE06PharmGKBPA449738

Structure

InChIKeyXUBOMFCQGDBHNK-UHFFFAOYSA-NSMILESCOC1=C2N(C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNC(C)C1)C1CC1

Targets

P72524gyrAP0A4L9gyrBP72525parCQ59961parEP0A0K8gyrBP20831gyrA

Transporters

P08183ABCB1Q92887ABCC2

What you can answer from here — as of September 30, 2026

6Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

2TransportersSubstrate / inhibitor direction, not just membership

Listed above

974Drug interactionsStructured to mechanism, not free text

30Clinical trialsPhase, status and sponsor resolved per trial

3Structured indicationsCondition, population, route and combination as fields, not prose

1ContraindicationEach with its own population and attribute set

51Marketed productsAcross 7 countries and 27 labellers

2ATC codesIncluding every combination product, plus 27 drug categories

38+ReferencesStructured and connected to the statements they support

Which drugs share a target with Gatifloxacin, and which of those have an active Phase 3 trial?

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