DNA gyrase subunit B

BE0003725ProteinStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)gyrB

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. It is acted on by 1 drug in DrugBank.

Gene name
gyrB
UniProtKB entry
P0A4L9Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
648 residues · 72,237 Da
Also known as
5.6.2.2 · 5.99.1.3

Resolves to

Protein
UniProtP0A4L9UniProt nameGYRB_STRPN
Gene
GenBank1052803
Pharmacology
KEGGspn:SP_0806
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA gyrase subunit B, how selective are they, and which programs against it are still in active trials?

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