DNA topoisomerase 4 subunit A

BE0003726ProteinStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)parC

Topoisomerase IV is essential for chromosome segregation. It is acted on by 2 drugs in DrugBank.

Gene name
parC
UniProtKB entry
P72525Swiss-Prot
Cellular location
Cell membrane
Residues / weight
823 residues · 93,132 Da
Also known as
5.6.2.2 · 5.99.1.3 · Topoisomerase IV subunit A

Resolves to

Protein
UniProtP72525UniProt namePARC_STRPN
Gene
GenBank1490399
Pharmacology
KEGGspn:SP_0855
Structure
PDB2NOVPDB3FOEPDB3FOF
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA topoisomerase 4 subunit A, how selective are they, and which programs against it are still in active trials?

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