DNA topoisomerase 4 subunit B

BE0003727ProteinStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)parE

Topoisomerase IV is essential for chromosome segregation. It is acted on by 1 drug in DrugBank.

Gene name
parE
UniProtKB entry
Q59961Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
647 residues · 71,664 Da
Also known as
5.6.2.2 · 5.99.1.3 · Topoisomerase IV subunit B

Resolves to

Protein
UniProtQ59961UniProt namePARE_STRPN
Gene
GenBank1490399
Pharmacology
KEGGspn:SP_0852
Structure
PDB3FOEPDB3FOFPDB3K9F
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
7GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
11+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on DNA topoisomerase 4 subunit B, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In