Nuclear receptor coactivator 1

BE0003728ProteinHumansNCOA1

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. It is acted on by 21 drugs in DrugBank.

Gene name
NCOA1
UniProtKB entry
Q15788Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,441 residues · 156,755 Da
Also known as
2.3.1.48 · BHLHE74 · Class E basic helix-loop-helix protein 74 · NCoA-1 · Protein Hin-2

Resolves to

Protein
UniProtQ15788UniProt nameNCOA1_HUMAN
Gene
HGNCHGNC:7668NCBI Gene8648GenBank1480646GeneCardsNCOA1
Pharmacology
IUPHAR/GtoPdb2693KEGGhsa:8648
Structure
PDB1FM6PDB1FM9PDB1K4W
Drugs

What you can answer from here — as of September 07, 2019

21DrugsApproved to experimental, with action, bond type and pharmacological action
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19GO termsFunction, process and component, as structured annotations
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7Pfam domainsDomain architecture mapped to Pfam families and clans
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59+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Nuclear receptor coactivator 1, and which indications are they being tested in?

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