A disintegrin and metalloproteinase with thrombospondin motifs 5

BE0003730ProteinHumansADAMTS5

Metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. It is acted on by 6 drugs in DrugBank.

Gene name
ADAMTS5
UniProtKB entry
Q9UNA0Swiss-Prot
Cellular location
Secreted, extracellular space, extracellular matrix
Residues / weight
930 residues · 101,717 Da
Also known as
3.4.24.- · A disintegrin and metalloproteinase with thrombospondin motifs 11 · ADAM-TS 11 · ADAM-TS 5 · ADAM-TS5

Resolves to

Protein
UniProtQ9UNA0UniProt nameATS5_HUMAN
Gene
HGNCHGNC:221NCBI Gene11096GenBank5733438GeneCardsADAMTS5
Pharmacology
IUPHAR/GtoPdb1678KEGGhsa:11096
Structure
PDB2RJQPDB3B8ZPDB3HY7
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which compounds in development act on A disintegrin and metalloproteinase with thrombospondin motifs 5, and which indications are they being tested in?

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