Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

BE0003731ProteinHumansGNAS

Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:12391161, PubMed:17110384, PubMed:21488135, PubMed:26206488, PubMed:8702665, PubMed:10200251). It is acted on by 2 drugs in DrugBank.

Gene name
GNAS
UniProtKB entry
P63092Swiss-Prot
Cellular location
Cell membrane
Residues / weight
394 residues · 45,664 Da
Also known as
3.6.5.- · Adenylate cyclase-stimulating G alpha protein · GNAS1 · GSP

Resolves to

Protein
UniProtP63092UniProt nameGNAS2_HUMAN
Gene
HGNCHGNC:4392NCBI Gene2778GenBank31915GeneCardsGNAS
Pharmacology
KEGGhsa:2778
Structure
PDB5G53PDB5UZ7PDB5VAI
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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22GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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51+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, and which indications are they being tested in?

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