Colforsin

DB02587InvestigationalSmall molecule

Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant Coleus forskohlii. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities;...

Mechanism: Pharmacologically active on RAF proto-oncogene serine/threonine-protein kinase, Nuclear receptor subfamily 1 group I member 2, and Solute carrier family 2, facilitated glucose transporter member 1
Curator reviewed
Formula / weight: C₂₂H₃₄O₇ · 410.5012 g/mol (avg)
Also known as: Coleonolk · Forskolin
Code names: 266-410-9 · HL-362 · L-75-1362B · NSC-357088 · NSC-375489

Resolves to

Compound

UNII1F7A44V6OUCAS66575-29-9ChEMBLCHEMBL52606ChEBI42471PubChem47936KEGGD03584

Clinical / RWD

PharmGKBPA146096022

Structure

InChIKeyOHCQJHSOBUTRHG-KGGHGJDLSA-NSMILES[H][C@]1(O)CCC(C)(C)[C@]2([H])[C@]([H])(O)[C@]([H])(OC(C)=O)[C@@]3(C)O[C@](C)(CC(=O)[C@]3(O)[C@@]12C)C=C

Targets

P04049RAF1O75469NR1I2P11166SLC2A1P48764SLC9A3Q08462ADCY2P63092GNASO95622ADCY5P13569CFTR+3 more

Transporters

P08183ABCB1

What you can answer from here — as of September 23, 2026

14Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1TransporterSubstrate / inhibitor direction, not just membership

Listed above

3Drug interactionsStructured to mechanism, not free text

1Clinical trialPhase, status and sponsor resolved per trial

21+ReferencesStructured and connected to the statements they support

Which drugs share a target with Colforsin, and which of those have an active Phase 3 trial?

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