Cyclopropane mycolic acid synthase 1

BE0003738ProteinMycobacterium tuberculosiscmaA1

Catalyzes the conversion of a double bond to a cyclopropane ring at the distal position of an alpha mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. It is acted on by 3 drugs in DrugBank.

Gene name
cmaA1
UniProtKB entry
P9WPB7Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
287 residues · 32,461 Da
Also known as
2.1.1.79 · AdoMet-MT · CFA synthase · cma1 · CMAS

Resolves to

Protein
UniProtP9WPB7UniProt nameCMAS1_MYCTU
Gene
NCBI Gene887961
Pharmacology
KEGGmtu:Rv3392c
Structure
PDB1KP9PDB1KPGPDB1KPH
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
6GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
7+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Cyclopropane mycolic acid synthase 1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In